Increased c-kit (CD117) expression in malignant mammary phyllodes tumors
نویسندگان
چکیده
منابع مشابه
KIT (CD117) Expression in Benign and Malignant Sweat Gland Tumors
KIT (CD117, c-kit) is a receptor tyrosine kinase involved in the tumorigenesis of several neoplasms. KIT is expressed by the secretory cells of normal sweat glands. We studied the KIT expression and KIT mutational status in various benign and malignant tumors of eccrine and apocrine glands. We included a total of 108 cases comprising 10 benign and 6 malignant sweat gland tumors, and KIT express...
متن کاملEvaluation of c-KIT protein expression in canine mammary tumors
Background c-KIT is a proto-oncogene that synthesizes a tyrosine kinase protein responsible for cell growth. Higher expression of c-KIT protein in women normal breasts correlates with differentiation status of normal breast epithelium, while loss of c-KIT expression is observed during progression or malignant transformation of mammary epithelium. In bitches the role of this tyrosine kinase rece...
متن کاملAn approach to malignant mammary phyllodes tumors detection.
BACKGROUND/AIM Mammary phyllodes tumors (MPT) are uncommon fibroepithelial (biphasic) neoplasms whose clinical behavior is difficult to predict on the basis of histological criteria only. They are divided into benign, borderline malignant and malignant groups. Sometimes it appears difficult to distinguish these tumors from other types of soft tissue sarcomas. Because of the relatively scant dat...
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BACKGROUND Phyllodes tumors (PTs) represent uncommon fibroepithelial lesions of the breast that express c-Kit and platelet-derived growth factor receptor-alpha, similar to gastrointestinal stromal tumors (GISTs). 'Activating' mutations in these genes underlie responsiveness of GISTs to imatinib. Standard treatment for breast PTs is wide local excision, with no role for targeted therapies. PAT...
متن کاملClassification and grading of canine malignant mammary tumors
Histological grading is a good parameter to stratify tumors according to their biological aggressiveness. The Elston and Ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. The aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. The samples included ...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2004
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.3800125